Tesamorelin is a growth hormone–releasing peptide (GHRP) analog studied for its ability to increase natural growth hormone (GH) and IGF-1 levels. It’s been most widely researched for reducing visceral fat (deep abdominal fat) while preserving lean muscle mass.
How Tesamorelin Works
Tesamorelin signals your pituitary gland to release more of your body’s own GH. This hormone supports:
– Fat metabolism: Promotes breakdown of stored fat for energy.
– Muscle preservation: Helps maintain lean muscle tissue during calorie deficits.
– Recovery & repair: GH supports tissue regeneration and recovery after training.
– Sleep quality: Many report improved deep sleep and energy.
Reported Benefits
– Reduction in visceral (organ) fat
– Preservation or gain of lean muscle
– Improved recovery and workout performance
– Enhanced sleep and mood
– Support for healthy metabolism
Potential / Reported Side Effects
– Mild water retention
– Tingling in hands or feet
– Joint stiffness or muscle aches
– Fatigue or temporary bloating
– Injection site irritation
⚠️ GH-related peptides may influence cell growth pathways. Not recommended for individuals with certain health conditions. Always discuss your full health history and recent lab work with a licensed provider before beginning.
Basic Reconstitution Example (10 mg Vial)
For educational purposes only.
– Mix 2 mL bacteriostatic water (BAC) into the 10 mg vial.
– This yields 5 units = 250 mcg, 10 units = 500 mcg, 15 units = 750 mcg.
– Store refrigerated and handle using sterile technique.
(This is for reference only. Always consult your provider for personalized dosing and administration.)
Common Use Pattern
Tesamorelin is often taken daily, typically 5 days on / 2 days off, for best GH pulse support. For users focused on performance or physique goals, it’s sometimes paired with CJC-1295/Ipamorelin for enhanced GH release, or IGF-1 LR3 for muscle growth signaling.
Best Practices
– Stay consistent — GH release is rhythm-based.
– Keep protein intake high to support lean muscle retention.
– Combine with strength training for optimal results.
– Monitor progress every 4–6 weeks and adjust with your provider.
Clinical Background
Tesamorelin was FDA-approved for HIV-associated lipodystrophy, with studies showing:
– Up to 15–18% reduction in visceral fat over 6 months
– No major impact on subcutaneous fat or lean muscle
– Sustained effects with consistent use and proper nutrition
(References: J Clin Endocrinol Metab. 2012;97(7):2313-2321, NEJM 2010;362:1151-116The Journal of Clinical Endocrinology & Metabolism, Volume 97, Issue 12, 1 December 2012, Pages 4769–4779,0) Click Here for the study.
Educational Notes
Tesamorelin is not a magic fix — it works best when paired with proper sleep, nutrition, and training. Think of it as a tool to enhance your body’s own repair and metabolism, not a replacement for effort.
Helpful Tools & Resources
Peptide Calculator – for quick reconstitution and unit conversions
Safe Sourcing Checklist – to verify trusted research suppliers
Tesamorelin Research Studies – full data and clinical papers
➡️ Click here for my preferred source
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