Tirzepatide (GLP-1/GIP Dual Agonist)
Disclaimer: This page is for educational purposes only and is not medical advice. Always consult with a licensed provider before starting any peptide or GLP therapy.
What is Tirzepatide?
Tirzepatide is a dual GLP-1 and GIP receptor agonist originally researched for type 2 diabetes management. It has since gained recognition in research studies for its ability to support:
– Appetite regulation and satiety
– Improved blood sugar control
– Metabolic health
– Weight reduction and body composition improvements
Reported Benefits
– Reduces appetite and food cravings
– Supports healthy glucose regulation
– Promotes gradual weight reduction
– May improve insulin sensitivity
– Helps preserve lean muscle when paired with proper diet & resistance training
Potential / Reported Side Effects
– Nausea, stomach discomfort, bloating
– Constipation or diarrhea
– Occasional fatigue or headache
– Possible injection site irritation
– Rare: reported cases of low blood sugar (especially with other glucose-lowering agents)
Note: These side effects are often dose-dependent and may lessen as the body adjusts.
Reconstitution (Example)
A common preparation for research vials:
– 10mg vial reconstituted with 2mL BAC water
– Final concentration = 5mg per mL
– 1mg = 20 units (on an insulin syringe)
Titration Schedule (Research Example)
| Week | Dose (Example) | Notes |
| Weeks 1–4 | 2.5 mg once weekly | Starter phase to minimize GI side effects |
| Weeks 5–8 | 5 mg once weekly | Standard effective dose for many users |
| Weeks 9–12 | 7.5 mg once weekly | Escalation for improved results if tolerated |
| Weeks 13–16 | 10 mg once weekly | Mid-range clinical dose |
| Weeks 17–20 | 12.5 mg once weekly | Higher dose, increased appetite suppression |
| Weeks 21+ | 15 mg once weekly | Max studied dose in clinical trials |
Safe Example Titration (Simplified)
For individuals new to GLPs, many find slower escalation schedules easier to tolerate. A safe approach often looks like:
– Start: 2.5mg once weekly
– Increase by 2.5mg every 4 weeks (if tolerated)
– Most stop between 5–10mg weekly depending on goals & response
Tip for Consistency
Many researchers and providers recommend staying at the lowest effective dose that gives you consistent results. This helps minimize side effects while maintaining steady progress over time. More isn’t always better — finding your “sweet spot” is usually the key to long-term success.
Provider Option
If the DIY side of research feels overwhelming, there are also 503A compounding pharmacies that handle everything for you. They provide lab work, consultations, and walk you through the entire process step by step. If that’s a better fit for your situation, click here for my preferred source — they’ll make sure you’re covered safely and effectively.
Retatrutide vs Tirzepatide: Titration Comparison
| Retatrutide | Tirzepatide |
| Start: 1mg once weekly | Start: 2.5mg once weekly |
| 2mg once weekly after 4 weeks | 5mg once weekly after 4 weeks |
| 3–4mg once weekly (trial midpoint) | 7.5–10mg once weekly (trial midpoint) |
| 5–8mg once weekly (higher clinical range) | 12.5–15mg once weekly (higher clinical range) |
Note: Retatrutide is generally considered more potent per mg due to its triple agonist design, while Tirzepatide is dual-acting but with wider clinical dosing ranges.
Trusted Sources
I maintain a list of vetted suppliers with COAs and consistent quality on my resources page. I personally use the first source listed.
View Safe Sourcing
Preferred Source (Direct)
Note: Links are for research convenience; no claims of diagnosis, treatment, cure, or prevention are made.
Resources
For sourcing checklists, calculators, and additional peptide education tools, visit KempCoreFitness.com
For education only. Discuss changes, side effects, and lab monitoring with a licensed provider. Pair metabolic protocols with adequate protein intake and resistance training to preserve lean mass.
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